چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Background: Advanced age is associated with a decline in natural oocytes, low oocyte yield, increases in the rate of infertility treatment cancellation, and a probable decrease in pregnancy rate. Platelet-rich plasma (PRP) is one of the proposed therapeutic strategies for women with poor ovarian response. Because of the autologous source of PRP, the lowest risks for disease transmission, immunogenic and allergic reactions have been expected. This study aimed to evaluate the single-dose intraovarian injection of autologous platelet-rich plasma in poor ovarian reserve. Materials and Methods: A before-after study was conducted between April and May 2021 in Al-Zahra hospital and Milad infertility clinic in Tabriz, Iran. A total of thirty-five women with a poor ovarian response (POR) and mean age 40.68±0.34 enrolled in the study. Following injection of autologous PRP into the ovaries, the number of oocytes, antral follicles, and level of estradiol, anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), luteal hormone (LH), FSH / LH ratio also were evaluated before and after treatment. Results: At the 2-month follow-up, women treated with PRP showed a significant elevation in the number of oocytes (3.68±0.24, P<0.001) and embryos (3.17±0.14, P<0.001), as well as in the estradiol levels (404.1±16.76 VS 237.7±13.14, P<0.001). Conclusion: Single PRP injection is effective and might be a promising therapeutic approach in patients with poor ovarian response to conceive with their own oocytes, although further evidence is required to assessing the influence of PRP on the live birth rate. |
| نویسنده | نفر چندم مقاله |
|---|---|
| نازلی نوالی | اول |
| لعیا فرزدی | سوم |
| کبری حمدی | پنجم |
| بهروز نیک نفس | هفتم |
| پروین حکیمی | ششم |
| عالیه قاسم زاده | چهارم |
| لیلا صادقی | دوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Navali.pdf | 1400/12/24 | 605186 | دانلود |
