چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| جلال اعتمادی خیاوی | اول |
| رزا متولی خیاوی | دوم |
| سیده مینا حجازیان | سوم |
| سپیده زنونی واحد | چهارم |
| ثمانه عباسیان | پنجم |
| محمد رضا اردلان | ششم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Introduction: IgA autoantibodies against (b2-glycoproteinI (b2-GPI) are linked with cardiovascular and thrombotic events and death in patients with chronic kidney disease (CKD). Identification of risk factors can improve management strategies. The aim of this study was to compare the levels of these antibodies in patients undergoing hemodialysis and peritoneal dialysis. Methods: The presence of anti-b2-GPI IgA auto-antibodies was evaluated in a cohort of 115 patients under hemodialysis (HD, n= 73) and peritoneal dialysis (PD, n=42). Moreover, retrospective data on the incidence of myocardial infarction and cerebrovascular accident (CVA), arteriovenous fistula (AVF) failure, and history of peritonitis were analyzed. Results: Forty-six (40%) of patients were positive for IgA-ab2-GPI with median levels of 74.95 U/mL (IRQ = 47.27). Anti-IgA-ab2- GPIantibodies titer was higher in HD than PD group [median 76.35 (47) vs. 63.85 (56.35)]; however, it was statistically insignificant (p = 0.721). AVF thrombosis occurred in 12% and 28.6% of patients in HD and PD, respectively (p = 0.030). There was no significant difference between AVF failure and lgA-aP2-GPI positivity (p = 0.0901). Sixty-one percent of PD patients had a history of peritonitis, 21.4% (n = 9) of which were positive for IgA-ab2GPI (p = 0.554). Positive lgA-aP2-GPI increased the risk of thrombotic events (CVA and MI) (OR= 2.43, CI: 0.65-9.17. p = 0.18), it was not statistically significant though. Conclusions: The results indicate that lgA-ap2GPI levels were not associated with the type of dialysis (HD, or PD). Moreover, the presence of anti-lgA-aP2-GPI in patients underlying dialysis may be linked with the incidence of thrombotic events |
| کلمات کلیدی | IgA ANTI-b2-GLYCOPROTEIN, HEMODIALYSIS, PERITONEAL DIALYSIS |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| B2GP Abstract KIR.pdf | 1400/12/23 | 152644 | دانلود |
| B2GP.pdf | 1400/12/23 | 1538994 | دانلود |
| B2GP WCN 2022 certification.pdf | 1400/12/23 | 497616 | دانلود |
