چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| جلال اعتمادی خیاوی | اول |
| رزا متولی خیاوی | دوم |
| ترانه مجیدی | سوم |
| سیده مینا حجازیان | چهارم |
| سپیده زنونی واحد | پنجم |
| ثمانه عباسیان | ششم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | GLUCOCORTICOID RECEPTOR, POLYMORPHISM, DIABETES, RENAL RECIPIENTS |
| خلاصه مقاله | Introduction: New-onset diabetes after transplantation (NODAT) is one of the severe metabolic complications after transplantation. Glucocorticoid receptor is encoded by NR3C1 gene and it seems that polymorphisms in this gene lead to sensitivity increase to insulin. Therefore, the aim of the study was to evaluate four common polymorphisms in the NR3C1 gene in kidney recipients with NODAT. Methods: Blood samples were collected from 32 NODAT and 59 nondiabetic renal-transplanted patients. After DNA extraction, ER22/ 23EK, A3669G, Bcl I, and N363S polymorphisms of the NR3C1 gene were amplified and directly sequenced using specific primers. Results: Results demonstrated that there was no correlation between diabetes incidence and four investigated polymorphisms of glucocorticoid receptor gene. Nevertheless, it was determined that diabetic patients’ age were higher than non-diabetic patients. There was a significant association between NODAT and acute rejection. Conclusions: Based on gathered information in this research, nor inhibitor or resonator polymorphisms had an effect on NODAT development in the Azari population. Further investigations should be performed with a large sample size. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| NODAT.pdf | 1400/12/23 | 1529116 | دانلود |
| NODAT Abstract KIR.pdf | 1400/12/23 | 101303 | دانلود |
| NODAT WCN 2022 certification.pdf | 1400/12/23 | 497353 | دانلود |
