چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| فریبا میرزائی باویل | اول |
| محمدرضا علیپور | دوم |
| گیسو محدث | سوم |
| رعنا کیهان منش | چهارم |
| علیرضا علی همتی | پنجم |
| فریبا قیاسی | ششم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Hypoxia; HIF-la; VEGF; Ghrelin; Liver |
| خلاصه مقاله | Introduction: Hypoxia is a condition of decreased availability of oxygen. When cells are exposed to a low oxygen environment, they impel the hypoxia responses to adapt to new situation. The hypoxia response leads to the activation of various cellular signaling pathways. The aim of this study was to evaluate the effect of ghrelin on angiogenesis, HIF-1 and VEGF levels in hypoxia situation. Methods: Twenty four animals were divided into 4 groups (n-6): control (C), ghrelin (Gh), hypoxia (1), and hypoxic animals that received ghrelin (H+Gh). Hypoxia (11%) was induced by an Environmental Chamber System GO2 Altitude. Animals in ghrelin groups received a IP injection of ghrelin (150 µg/kg/day) for 14 days Results: Our results show that hypoxia significantly (p<0.05) increased angiogenesis without any significant changes on HIF-1 and VEGF levels, whereas ghrelin significantly (p0.05) decreased angiogenesis, expression of HIF-1 and VEGF in this condition. Ghrelin administration did not show any significant changes in normal conditions. Conclusion: Ghrelin had no effect on angiogenesis, expression of HIF-I and VEGF in normal xygen conditions but it reduced angiogenesis process in liver tissue with reducing the level of HIF and VEGF in hypoxic condition. Therefore, effect of ghrelin on angiogenesis could be related to oxygen level in environment. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| serti.jpeg | 1400/12/21 | 65750 | دانلود |
| con22-2.jpeg | 1400/12/21 | 69430 | دانلود |
