چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| زهره زواری اسکویی | اول |
| رعنا کیهان منش | دوم |
| فریبا میرزائی باویل | سوم |
| کیوان مهری | چهارم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Troxerutin, Diabetes, Testosterone, Leydig cells, Testis |
| خلاصه مقاله | Background and Objective: Diabetes can gradually cause damage to the function and structure of male gonads. Our previous studies showed that troxerutin has a suitable anti-hyperglycemic effect. This study was conducted to investigate the effect of troxerutin on function and total number of Leydig cells in type I diabetic adult male rats. Materials and Methods: Fifty adult male Wistar rats randomly divided into 5 groups including control, troxerutin, diabetes, diabetes+troxerutin and diabetes+insulin. Diabetes was induced by 55 mg/kg streptozotocin. Diabetes+insulin group received 4-6 U/day insulin NPH. Troxerutin and diabetes+troxerutin groups received 150 mg/kg troxerutin via oral gavage for 4 weeks. At the end of experiment, animals were anaesthetized and plasma samples were taken for measurement of testosterone by ELISA. Testes were fixed in formalin, processed by standard paraffin embedding and tissue sections were stained by H&E. Total numbers of Leydig cells were estimated by optical fractionator and stereo-investigator software. One-way ANOVA and Tukey's post-hoc were performed for data analysis. Results: The results showed that diabetes reduced plasma level of testosterone and total Leydig cells significantly compared to control groups. It was indicated that troxerutin and insulin increased plasma level of testosterone and Leydig cells number significantly compared to diabetic group. However total number of Leydig cells in troxerutin and insulin treated groups was significantly lesser that control but testosterone level had not significant diffrences with control group. Conclusion: This study revealed that troxrutin treatment can be considered as a suitable protective strategy for increasing of fertility in diabetic males. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| chabahar cong.pdf | 1400/12/21 | 891528 | دانلود |
| con 24th.jpeg | 1400/12/21 | 95085 | دانلود |
