| خلاصه مقاله | Wound healing is a complicated and tightly regulated process that is essential to
restore the normal barrier function of the skin, thereby preventing further damage or
infection. The normal wound healing process involves sequential but overlapping
phases, including inflammation, proliferation, and remodeling. These phases are
mediated by a range of cell types including fibroblasts, keratinocytes, endothelial
cells, and macrophages, the activity of which is carefully coordinated by a range of
growth factors, cytokines, and chemokinesChronic wounds, comprising surgical
wounds, vascular leg ulcers, diabetic foot ulcers, and pressure ulcers, represent a
significant burden to the individual and to the healthcare system. delay or failure of a
chronic wound to heal. the most important factor that can affect the healing of a
chronic wound. “window of opportunity” is thought to exist after debridement
during which biofilms are more susceptible to treatment, in particular topical
antiseptics. By delaying biofilm reformation after debridement, topical antiseptics
may reduce the risk of infection and subsequent need for antibiotics, helping to
minimize the potential for antibiotic resistance to develop |