چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia among the elderly population. AD is accompanied with the dysregulation of specifc neurotrophic factors (NTFs) and their receptors, which plays a critical role in neuronal degeneration. NTFs are small proteins with therapeutic potential for human neurodegenerative diseases. These growth factors are categorized into four families: neurotrophins, neurokines, the glial cell line-derived NTF family of ligands, and the newly discovered cerebral dopamine NTF/mesencephalic astrocyte-derived NTF family. NTFs are capable of preventing cell death in degenerative conditions and can increase the neuronal growth and function in these disorders. Nevertheless, the adverse side efects of NTFs delivery and poor difusion of these factors in the brain restrict the efcacy of NTFs therapy in clinical situations. Materials and methods In this review, we focus on the current advances in the use of NTFs to treat AD and summarize previous experimental and clinical studies for supporting the protective and therapeutic efects of these factors. Conclusion Based on reports, NTFs are considered as new and promising candidates for treating AD and AD-associated cognitive impairment. |
| نویسنده | نفر چندم مقاله |
|---|---|
| جواد محمودی | چهارم |
| خدیجه دیزجی اصل | پنجم |
| زهرا شعبانی | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 1.pdf | 1400/12/16 | 853758 | دانلود |
