چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Neuregulin-1β (NRG-1β) is associated with cardiomyocyte proliferation and cardioprotection. Therefore, in the present study, the effect of acute and chronic exercise on plasma levels of NRG-1β and its association with cardiac hypertrophy in athlete and non-athlete women was investigated. Eighteen sedentary and 18 athlete women performed the Bruce test on a treadmill (acute) and 12 thrice-weekly sessions of water aerobic exercise (chronic). Plasma levels of NRG-1β were measured in all participants before and immediately after acute exercise, as well as, 24h and 72h after chronic exercise using ELISA kit. Moreover, echocardiographic parameters were analyzed before and after the exercise. The athletes had higher man levels of left ventricular end-diastolic diameter index (LVEDDI) and left ventricular mass index (LVMI) compared to the non-athletes before exercise. Moreover, 12-week exercise could significantly increase LVEDDI levels only in the non-athlete group. Plasma levels of NRG-1β were significantly higher in athletes than non-athletes. We found that chronic but not acute exercise could significantly increase levels of NRG-1β in both groups. The levels of NRG-1β were significantly lower three days after chronic exercise in comparison with 24h post-exercise in the non-athlete group. Plasma levels of NRG-1β had positive correlations with LVEDDI and LVMI in both groups. In conclusion, this study showed that chronic exercise could increase plasma levels of NRG-1β. Furthermore, the positive correlation between NRG-1β levels and cardiac hypertrophy indices suggests a role for NRG-1 in exercise-induced hypertrophy. |
| نویسنده | نفر چندم مقاله |
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| صبا نیکان فر | سوم |
| امیر فتاحی | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Neuregulin-1.pdf | 1400/12/15 | 417888 | دانلود |
