چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| سعید چارسوئی | اول |
| عنوان | متن |
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| خلاصه مقاله | Management of epilepsy caused by focal cortical dysplasia Saeid Charsouei ,MD,Assistant Professor of Neurology,Fellowship in Epilepsy , Tabriz University of Medical Sciences The incidence of Focal Cortical Dysplasia (FCD) is almost 50% of all the cases of intractable epilepsy identified in adults and children. Antiepileptic drugs (AEDs) have been widely used in the treatment of FCD. However, evidence to suggest their specific effect in the treatment of FCD remains to be established. Although treatment currently involves surgical management, non invasive treatments have been identified. non-invasive management strategies including, 1-mammalian target of rapamycin (mTOR)inhibitors, 2- ketogenic diet (KD), and 3- vagus nerve stimulation (VNS). Commonly used drugs in the treatment of drug-resistant epilepsy are broad spectrum AEDs such as levetiracetam, topiramate, and zonisamide for their multiple mechanisms of action. Epileptic seizures in focal cortical dysplasia are difficult to control with pharmacological treatment and often intractable. Hence, the surgical treatment appears to be a next therapeutic procedure. The resection of lesion, lobectomies and even hemispherectomies are performed. More limited surgeries are performed in elderly patients, usually due to FCD type I, usually located within the temporal lobe. Younger patients usually have FCD type II, with more extensive lesions and extratemporal location, predominantly in the frontal areas. In these cases operation includes lobectomy/ies or even hemispherectomy . According to the literature, 60–80% of patients remain seizure-free after surgery, depending on the study center . |
| کلمات کلیدی | epilepsy,focal cortical dysplasia,management |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Certificate.pdf | 1400/12/07 | 492795 | دانلود |
| FCD Final -converted.pdf | 1400/12/08 | 1733937 | دانلود |
| govahi congre 1400.jpg | 1400/12/08 | 143040 | دانلود |
