| In the current decade, a growing body of evidence has proposed the correlation between diet
and cognitive function or dementia in the ageing population. This study was designed to appraise
discoveries from the randomized controlled trials to confrm the efects of berry-based supplements
or foods on cognitive function in older adults. PubMed/MEDLINE, Cochrane Central Register of
Controlled Trials, Web of Science, Scopus, EMBASE, Google Scholar, and ProQuest as well as SID,
Magiran, and Iranmedex electronic databases were explored for human interventional studies up to
March 2021. In total, eleven articles were identifed using frozen blueberry (n= 4 studies), blueberry
concentrate (n= 2), beverage (n= 3), capsule (n= 1), extract and powder (n= 1). These studies had been
performed among older people with no recognized cognitive impairment or mild cognitive impairment
(MCI). The primary outcomes included global cognitive function, psychomotor function, learning
and memory, working memory capacity, executive functions, and brain perfusion/activity. To our
knowledge, this is the frst systematic review of available clinical trials on the efects of berry-based
supplements and foods on cognitive performances as well as brain perfusion parameters among the
elderly with normal cognition or MCI. Existing evidence concludes that berry-based supplements and
foods have benefcial efects on resting brain perfusion, cognitive function, memory performance,
executive functioning, processing speed, and attention indices. |