The effects of lemon balm (Melissa officinalis L.) on depression and anxiety in clinical trials: A systematic review and meta‐analysis
The effects of lemon balm (Melissa officinalis L.) on depression and anxiety in clinical trials: A systematic review and meta‐analysis
نویسندگان: جاوید قاضی زاده , سعید صدیق اعتقاد , علی فخاری دهخوارقانی , ساناز حامدیزدان , محمدعلی تربتی , سمیه طاهری طرقی , سید مصطفی اعرج خدایی , مژگان میرغفوروند
کلمات کلیدی: Melissa officinalis; anxiety; depression; lemon balm; systematic review
نشریه: 27548 , 12 , 35 , 2021
| نویسنده ثبت کننده مقاله |
سید مصطفی اعرج خدایی |
| مرحله جاری مقاله |
تایید نهایی |
| دانشکده/مرکز مربوطه |
مرکز تحقیقات طب تلفیقی |
| کد مقاله |
78168 |
| عنوان فارسی مقاله |
The effects of lemon balm (Melissa officinalis L.) on depression and anxiety in clinical trials: A systematic review and meta‐analysis |
| عنوان لاتین مقاله |
The effects of lemon balm (Melissa officinalis L.) on depression and anxiety in clinical trials: A systematic review and meta‐analysis |
| ناشر |
9 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ |
بلی |
| عنوان نشریه (خارج از لیست فوق) |
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| نوع مقاله |
Systematic Review Article |
| نحوه ایندکس شدن مقاله |
ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
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| A systematic review and a meta-analytic approach were considered to investigate the effects of lemon balm as a medicinal herb on anxiety and depression in clinical trials and its side effects. All randomized clinical trials published up to October 30, 2020 that examined lemon balm in patients with symptoms of depression or anxiety, with acute or chronic manifestations, were searched in 12 online databases. Statistical analysis was performed using RevMan software. Continuous data were analyzed using standardized mean differences. Statistical heterogeneity was assessed using Chi2, I2, and p value tests. Based on meta-analysis results, lemon balm significantly improved mean anxiety and depression scores compared with the placebo (SMD: -0.98; 95% CI: −1.63 to −0.33; p = 0.003), (SMD: -0.47; 95% CI: −0.73 to −0.21; p = 0.0005) respectively, without serious side effects. Current evidence suggests that lemon balm may be effective in improving anxiety and depressive symptoms, particularly in the acute setting. Due to the high level of heterogeneity between studies, results should be interpreted with caution. The small number of clinical trials and differences between their methods were the limitations of the present study. Further high-quality studies are needed to firmly establish the clinical efficacy of the lemon balm. |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| Melissa officinalis.pdf | 1400/12/03 | 7035073 | دانلود |