| Hydrogels are widely used for wound healing applications due to their similarity to the native extracellular matrix (ECM) and ability to provide a moist environment. However, lack of multifunctionality and low mechanical
properties of previously developed hydrogels may limit their ability to support skin tissue regeneration. Incorporating various biomaterials and nanostructures into the hydrogels is an emerging approach to develop multifunctional hydrogels with new functions that are beneficial for wound healing. These multifunctional hydrogels can
be fabricated with a wide range of functions and properties, including antibacterial, antioxidant, bioadhesive, and
appropriate mechanical properties. Two approaches can be used for development of multifunctional hydrogelbased dressings; taking the advantages of the chemical composition of biomaterials and addition of
nanomaterials or nanostructures. A large number of synthetic and natural polymers, bioactive molecules, or
nanomaterials have been used to obtain hydrogel-based dressings with multifunctionality for wound healing applications. In the present review paper, advances in the development of multifunctional hydrogel-based dressings for wound healing have been highlighted. |