چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | وحدت پورطهماسبی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | بیماری های عفونی و گرمسیری |
| کد مقاله | 78085 |
| عنوان فارسی مقاله | Transcriptional signature analysis of PBMCs in early stage of hepatitis B related hepatocellular carcinoma |
| عنوان لاتین مقاله | Transcriptional signature analysis of PBMCs in early stage of hepatitis B related hepatocellular carcinoma |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | 13th International Congress of Medial Laboratory and Clinic |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1400 |
| سال انتشار/ارائه میلادی | 2022 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1400/11/16 الی 1400/11/20 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://congressapp.ir/isacl2022/poster_view.php?id=799 |
| آدرس علمی (Affiliation) نویسنده متقاضی | Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| نادر محمدزاده | اول |
| وحدت پورطهماسبی | چهارم |
| حسین بنازاده باغی | سوم |
| بهروز نقیلی حکم آبادی | هفتم |
| مجتبی ورشوچی فرد | هشتم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Chronic hepatitis B; Hepatocellular carcinoma; Differentially expressed genes |
| خلاصه مقاله | Background and Aim: Hepatocellular carcinoma (HCC) is a common malignant tumor with high morbidity and mortality. The appropriate prediction of diagnosis and prognosis is of great emphasis to improve the survival rate of patients. This study aims to evaluate gene expression levels of previously identified transcripts for chronic hepatitis B (CHB) and HCC patients. Methods: To evaluate previously analyzed transcriptome array data, we selected seven differentially expressed genes (DEGs) that were common in normal vs CHB and CHB vs HCC patients (CD44, SP3, USP8, E2F2, UFM1, IRF2BP2, and TIA1). To this goal, the study included individuals with treatment naïve CHB (n=30), primary HCC (n=25), and healthy control (n=15). Subsequently, the expression of genes was assayed using qRT-PCR. Phylogenetic analysis was applied using direct sequencing on HBsAg. Results: In HCC patients, 60 % (n = 15) were positive for HBeAg. None of the CHB patients were positive for HBeAg, but all were positive for anti-HBe. HBV load was significantly higher in HCC patients than CHB subjects. All patients were ethnically Iranian and HBV genotype D. There was a higher expression of five transcriptional signatures (CD44, SP3, USP8, E2F2, and UFM1) in patients with HCC than CHB and healthy subjects, which was more approximately consistent with the results of the initial microarray data analysis. Conclusion: The findings indicate that transcriptional signatures may be associated with HCC pathogenesis and serve as diagnostic biomarkers for monitoring and early diagnosis of HCC. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 13th ISACL Abstract Book-2.pdf | 1400/11/23 | 5527619 | دانلود |
| Transcriptional signature Vahdat Poortahmasebi.jpg | 1400/11/23 | 381244 | دانلود |
