چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Objective: The aim of the present study was to assess the interaction of major dietary patterns with Cocaine- and Amphetamine-Regulated Transcript (CART) prepropeptide gene rs2239670 variant in apparently healthy obese Iranians. Methods: A total of 288 apparently healthy obese participants aged 20e50 years were recruited in this cross-sectional study. Usual dietary intake was assessed using a 147-item semi-quantitative validated food frequency questionnaire. Genotyping of the CART gene rs2239670 polymorphism was conducted by the polymerase chain reaction-restriction fragment length polymorphism (PCReRFLP). Results: The results showed that the majority of the participants had GG genotype (65.4%). Three dietary patterns were extracted: prudent dietary pattern (PDP), legume dietary pattern (LDP), and mixed dietary pattern (MDP). There were significant interactions between PDP and rs2239670 variant on fat free mass (FFM) (p Interaction ¼ 0.039), basal metabolic rate (BMR) (p Interaction ¼ 0.039). Also, significant interactions were observed between LDP and rs2239670 polymorphism on the diastolic blood pressure (DBP) (p Interaction ¼ 0.026), waist to hip ratio (WHR) (p Interaction ¼ 0.050), agouti-related protein (AgRP) (p Interaction ¼ 0.012), and a-melanocyte stimulating hormone (a-MSH) (p Interaction ¼ 0.006). Conclusions: The CART rs2239670 SNP interacts with dietary patterns to affect some of the cardiometabolic risk factors. |
| نویسنده | نفر چندم مقاله |
|---|---|
| مهدیه عباسعلیزاد فرهنگی | سوم |
| مهدیه خدارحمی | اول |
| مهدی نیک نام | دوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| niknam.pdf | 1400/11/20 | 1392130 | دانلود |
