چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| The appropriate endodontic material should eliminate the infection and inflammation to provide a situation for regeneration a healing of pulp tissue besides biomineralization. Chrysin is one of the active ingredients of plant flavonoids, which has signific anti-inflammatory and antimicrobial properties. In the present study, this natural substance was evaluated for antioxidant, an inflammatory, and mineralization properties on dental pulp stem cells (DPSCs). SEM, FTIR, and TGA tests were used determine the successful synthesize of chrysin-loaded scaffolds. The antimicrobial effects of the synthesized scaffold agai Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, and Enterococcus faecalis were assessed by the a diffusion test and live/dead assay. The proliferation of DPSCs on these scaffolds was determined by the MTT assay, DA staining, and DNA extraction. Moreover, the antioxidant and anti-inflammation activity of chrysin-loaded scaffolds on inflam DPSCs was evaluated. Alkaline phosphatase activity and Alizarin Red S Stain tests were done to evaluate the mineralization DPSCs seeded on these scaffolds. The chrysin-loaded scaffolds reported antimicrobial effects against evaluated bacterial strai The proliferation of DPSCs seeded on these scaffolds was increased significantly (p < 0:05). The TNFα and DCF levels inflamed DPSCs showed a significant decrease in the presence of chrysin-loaded scaffolds (p < 0:05). The ALP activity a formation of mineralized nodules of DPSCs on these scaffolds were significantly increased compared with the control gro (p < 0:05). These results indicated that chrysin as an ancient therapeutic agent can accelerate the healing and regeneration damaged pulp tissue, and this active ingredient can be a potential natural substance for regenerative endodontic procedures. |
| نویسنده | نفر چندم مقاله |
|---|---|
| مهدیه علیپور | اول |
| بهاره پویا | دوم |
| زهرا آقازاده | سوم |
| حسین صمدی کفیل | چهارم |
| مرجان قربانی | پنجم |
| سارا علیزاده | ششم |
| مرضیه آقازاده | هفتم |
| الهه دلیرعبدالهی نیا | هشتم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Ghorbani,2021,97.pdf | 1400/11/01 | 1612725 | دانلود |
