| خلاصه مقاله | Background
The complex interplay among infectious diseases and stroke is a matter of growing concern and
an ongoing research. Infections either leading to develop stroke or present as post stroke
infections, both are attributed as a major neurological apprehension of long-term morbidity and
mortality. Certain pathogens are well established either as an etiology or as predisposing factor
of stroke. Though many researchers have concentrated on relationship between infections and
stroke nevertheless, focusing on the risk factors and relationship of infection to timing of acute
stroke is a necessity.
Aim
To study the biomarkers associated with stroke and estimate their impact on outcome.
Materials and methods
This study was conducted on stroke patients (n=33) admitted to Razi Hospital, a University
based hospital under the auspices of Tabriz University of Medical Sciences, Tabriz. Patients’
were observed for predefined infections until discharge: urinary tract infection (UTI),
pneumonia, sepsis or any other infections e.g. Covid-19. Hypertension, smoking, diabetes
mellitus, atrial fibrillation, chronic heart disease, BMI dysfunction and mRS were studied as the
biomarkers.
Results
Thirty-three patients admitted to neurology ward and ICU were enrolled in the study. Patients of
all age groups and both genders were taken into the study. Those patients who were clinically
diagnosed not been afflicted by the stroke on the admission were excluded from the study. Of 33
stroke patients, 18 (54.5%) had ischemic stroke while, 12 (36.4%) suffered hemorrhagic stroke.
Only 3 (9.1%) patients had transient ischemic attack. The overall pooled infection rate was
51.5%; rates of pneumonia and UTI and Covid-19 positive were 15.2%, 21.2%, and 12.1%
respectively. Patients with ischemic stroke were more likely to be afflicted with UTI,
pneumonia, sepsis and other infections with rates of these infections ranged from 5.5% -27.7% in
these patients group as compared with hemorrhagic stroke patients (range of pooled infection
varied from 8.35 to 16.6%). Older age group (60-75 years) and more male (72.7%) showed
stroke. The modified Rankin Scale (mRS) calculated furnished following data in post stroke
patients: 6.1% dead (mRS 6), 18.2% severe disability (mRS 5), 12.1% moderately severe
disability (mRS 4), while 36.4% patients had slight disability (mRS3). Five patients did not show
any disability. Pre-stroke mRS score showed major (90.9%) patients did not possess any
disability (mRS 0). Patients with stroke were characterized by hypertension however, atrial
fibrillation, chronic heart disease, diabetes had partial effect in some patients only.
Conclusion
Patients with higher age, male gender and having clinical background of hypertension are some
of the predisposing factors of stroke. Ischemic stroke patients are more prone to get pneumonia,
UTI, sepsis and other infections in comparison to hemorrhagic stroke patients. |