چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Solubility data of pharmaceutical ingredients is required for crystallization, extraction and purification processes. The solubility profile and thermodynamic modeling of caffeine in the binary non-aqueous mixed solutions of N-methyl-2-pyrrolidone (NMP) and 1-propanol at various temperatures ranging from 293.2 to 313.2 K are measured in this study using a shake-flask method and the obtained data are fitted to some linear and a non-linear mathematical cosolvency models. Furthermore, the densities of caffeine saturated solutions are also determined and correlated with an adopted version of the Jouyban-Acree model. To study the accuracy of the applied models, the mean relative deviations of the back-calculated solubility and density data are computed. As well, the apparent thermodynamic properties of the caffeine dissolution process in the mixed solutions of NMP and 1-propanol are also calculated by using van’t Hoff and Gibbs equations and discussed. |
| نویسنده | نفر چندم مقاله |
|---|---|
| هما رضائی | اول |
| ابوالقاسم جویبان | دوم |
| الهه رحیم پور | پنجم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Solubility of caffeine in N-methyl-2.pdf | 1400/10/19 | 736213 | دانلود |
