ارتباط GFR کلیه و سطح سرمی کراتینین با اسکار کلیوی از اسکن 99mTc-Glucoheptonate در بیماران مبتلا به عفونت مجاری ادراری

The Association of Kidney’s GFR and Serum Creatinine Levels with Renal Scarring through 99mTc-Glucoheptonate Radiopharmaceutical Scan in Patients with Urinary Tract Infection


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نویسندگان: اشرف فخاری , اسماعیل قره پاپاق , ندا گیلانی , ناردین میرفخرائی , شهرام دبیری اسکوئی

کلمات کلیدی: Glomerular Filtration Rate, Urinary Tract Infection, Radionuclide Imaging, Creatinine, Radiation Protection

نشریه: 27159 , 2 , 28 , 2022

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نویسنده ثبت کننده مقاله اشرف فخاری
مرحله جاری مقاله تایید نهایی
دانشکده/مرکز مربوطه دانشکده پزشکی ,تیم های تحقیقاتی دانشگاه
کد مقاله 77810
عنوان فارسی مقاله ارتباط GFR کلیه و سطح سرمی کراتینین با اسکار کلیوی از اسکن 99mTc-Glucoheptonate در بیماران مبتلا به عفونت مجاری ادراری
عنوان لاتین مقاله The Association of Kidney’s GFR and Serum Creatinine Levels with Renal Scarring through 99mTc-Glucoheptonate Radiopharmaceutical Scan in Patients with Urinary Tract Infection
ناشر 6
آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ بلی
عنوان نشریه (خارج از لیست فوق) Pharmaceutical Sciences
نوع مقاله Original Article
نحوه ایندکس شدن مقاله ایندکس شده سطح یک – ISI - Web of Science
آدرس لینک مقاله/ همایش در شبکه اینترنت

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Abstract Background: UTI (urinary tract infection) is a leading case of renal scarring. Most of nephrons are found in kidney cortex, so it is important for early diagnosis of scarring. In this study, we investigated if scarring affects GFR (glomerular fltration rate) and serum level of creatinine through dual multipurpose 99mTc-GH (99mTc-Glucoheptonate) scintigraphy in patients with UTI. Methods: During this study 21 patients with UTI were studied by 99mTc-GH scan. For performing scintigraphy, the patient was injected by 370-555 MBq of 99mTc-GH and studied through two steps including dynamic (immediately afer injection) and static (2-3h afer injection) phases. Te results were evaluated by appropriate analytical methods. Moreover, fve patients were studied by both 99mTc-DMSA/GH (99mTc-dimercaptosuccinic acid and 99mTc-Glucoheptonate) to show 99mTc-GH scan is benefcial for detection of additional problems. Results: Te results showed that there is an association between right/lef kidney scarring and related GFR. Furthermore, the odds of decreased right and lef kidney GFR with scarring is 12.64 and 11.89 times more than normal kidney respectively. Also, there is a signifcant association between renal scarring and serum level of creatinine. Te study showed that the odds of increased serum level of creatinine in patients with scarring are 6.75 times more than patients without scarring. Moreover, the survey of fve patients with both 99mTc-DMSA/GH scans showed 99mTc-GH could be helpful with diagnosis of some renal problems as well as scarring. Conclusion: Trough this study by 99mTc-GH, it was demonstrated that kidney glomerular fltration rate and serum level of creatinine are associated with renal scarring. Furthermore, it was shown that 99mTc-GH scintigraphy could detect dilatation and abstraction of collection system in addition to renal scarring through static/dynamic renal scintigraphy.

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نویسنده نفر چندم مقاله
اشرف فخاریاول
اسماعیل قره پاپاقدوم
ندا گیلانیسوم
ناردین میرفخرائیچهارم
شهرام دبیری اسکوئیششم

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