ارتباط GFR کلیه و سطح سرمی کراتینین با اسکار کلیوی از اسکن 99mTc-Glucoheptonate در بیماران مبتلا به عفونت مجاری ادراری
The Association of Kidney’s GFR and Serum Creatinine Levels with Renal Scarring through 99mTc-Glucoheptonate Radiopharmaceutical Scan in Patients with Urinary Tract Infection
نویسندگان: اشرف فخاری , اسماعیل قره پاپاق , ندا گیلانی , ناردین میرفخرائی , شهرام دبیری اسکوئی
کلمات کلیدی: Glomerular Filtration Rate, Urinary Tract Infection, Radionuclide Imaging, Creatinine, Radiation Protection
نشریه: 27159 , 2 , 28 , 2022
| نویسنده ثبت کننده مقاله |
اشرف فخاری |
| مرحله جاری مقاله |
تایید نهایی |
| دانشکده/مرکز مربوطه |
دانشکده پزشکی ,تیم های تحقیقاتی دانشگاه |
| کد مقاله |
77810 |
| عنوان فارسی مقاله |
ارتباط GFR کلیه و سطح سرمی کراتینین با اسکار کلیوی از اسکن 99mTc-Glucoheptonate در بیماران مبتلا به عفونت مجاری ادراری |
| عنوان لاتین مقاله |
The Association of Kidney’s GFR and Serum Creatinine Levels with Renal Scarring through 99mTc-Glucoheptonate Radiopharmaceutical Scan in Patients with Urinary Tract Infection |
| ناشر |
6 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ |
بلی |
| عنوان نشریه (خارج از لیست فوق) |
Pharmaceutical Sciences |
| نوع مقاله |
Original Article |
| نحوه ایندکس شدن مقاله |
ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
|
| Abstract
Background: UTI (urinary tract infection) is a leading case of renal scarring. Most of nephrons
are found in kidney cortex, so it is important for early diagnosis of scarring. In this study, we
investigated if scarring affects GFR (glomerular fltration rate) and serum level of creatinine
through dual multipurpose 99mTc-GH (99mTc-Glucoheptonate) scintigraphy in patients with UTI.
Methods: During this study 21 patients with UTI were studied by 99mTc-GH scan. For performing
scintigraphy, the patient was injected by 370-555 MBq of 99mTc-GH and studied through two
steps including dynamic (immediately afer injection) and static (2-3h afer injection) phases.
Te results were evaluated by appropriate analytical methods. Moreover, fve patients were
studied by both 99mTc-DMSA/GH (99mTc-dimercaptosuccinic acid and 99mTc-Glucoheptonate) to
show 99mTc-GH scan is benefcial for detection of additional problems.
Results: Te results showed that there is an association between right/lef kidney scarring and
related GFR. Furthermore, the odds of decreased right and lef kidney GFR with scarring is 12.64
and 11.89 times more than normal kidney respectively. Also, there is a signifcant association
between renal scarring and serum level of creatinine. Te study showed that the odds of
increased serum level of creatinine in patients with scarring are 6.75 times more than patients
without scarring. Moreover, the survey of fve patients with both 99mTc-DMSA/GH scans showed
99mTc-GH could be helpful with diagnosis of some renal problems as well as scarring.
Conclusion: Trough this study by 99mTc-GH, it was demonstrated that kidney glomerular
fltration rate and serum level of creatinine are associated with renal scarring. Furthermore,
it was shown that 99mTc-GH scintigraphy could detect dilatation and abstraction of collection
system in addition to renal scarring through static/dynamic renal scintigraphy. |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| ps-28-314.pdf | 1401/01/22 | 2028700 | دانلود |
| rezayat.pdf | 1400/10/25 | 175364 | دانلود |
| akhlag.jpg | 1400/10/26 | 282266 | دانلود |