چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Knowledge of drug solubility is crucial and there is no available cosolvency database for baclofen, so far. In the current study, the solubility and density values of baclofen in five mono-solvents (i.e. methanol, ethanol, 1-propanol, 2-propanol and propylene glycol) and the binary mixed solvents of propylene glycol and ethanol within the temperature range of (293.2 –313.2) K are measured using shake-flask method followed by spectroscopy method. The generated data are correlated using some cosolvency models (e.g. the van’t Hoff, CNIBS/Redlich-Kister, the Jouyban-Acree, the Jouyban-Acree-van’t Hoff and λh models). The mean relative deviations for back-calculated solubility data were employed to investigate the accuracy of the models. Moreover, the apparent thermodynamic properties of dissolution of baclofen in the binary non-aqueous mixtures of solvents such as Gibbs free energy, entropy and enthalpy were computed using van't Hoff and Gibbs equations. |
| نویسنده | نفر چندم مقاله |
|---|---|
| هما رضائی | اول |
| الهه رحیم پور | دوم |
| محمد برزگر جلالی | پنجم |
| ابوالقاسم جویبان | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| baclofen.pdf | 1400/10/11 | 1002735 | دانلود |
