| Abstract
In recent years, stem cells have known as a helpful biological tool for the accurate
diagnosis, treatment and recognition of diseases. Using stem cells as biomarkers
have presented high potential in the early detection of many diseases. Another
advancement in stem cell technology includes stem cell derived organoids model
that could be a promising platform for diagnosis and modeling different diseases.
Furthermore, therapeutic capabilities of stem cell therapy have increased hope in the
face of different disability managements. All of these technologies are also widely
used in reproductive related diseases especially in today's world that many couples
encounter infertility problems. However, with the aid of numerous improvements in
the treatment of infertility, over 80% of couples who dreamed of having children
could now have children. Due to the fact that infertility has many negative effects on
personal and social lives of young couples, many researchers have focused on the
treatment of male and female reproductive system abnormalities with different
types of stem cells, including embryonic stem cells, bone marrow mesenchymal stem
cells (MSCs), and umbilical cord‐derived MSCs. Also, design and formation of reproductive system organoids provide a fascinating window into disease modeling,
drug screening, personalized therapy, and regeneration medicine. Utilizing these
techniques to study, model and treat the infertility‐related diseases has drawn attention of many scientists. This review explains different applications of stem cells in
generating reproductive system organoids and stem cell‐based therapies for male
and female infertility related diseases treatment. |