Pseudo High Serum Acetaminophen Levels in CKD Patients

Pseudo High Serum Acetaminophen Levels in CKD Patients


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نویسندگان: مریم زارع نهندی , فریما آفرند , حسن رضازاده , علی بناگذارمحمدی

عنوان کنگره / همایش: 18th International Congress of Nephrology, Dialysis and Transplantation Nephrology, Dialysis and , Iran (Islamic Republic) , تهران , 2021

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نویسنده ثبت کننده مقاله مریم زارع نهندی
مرحله جاری مقاله تایید نهایی
دانشکده/مرکز مربوطه مرکز تحقیقات کلیه
کد مقاله 77755
عنوان فارسی مقاله Pseudo High Serum Acetaminophen Levels in CKD Patients
عنوان لاتین مقاله Pseudo High Serum Acetaminophen Levels in CKD Patients
نوع ارائه پوستر
عنوان کنگره / همایش 18th International Congress of Nephrology, Dialysis and Transplantation Nephrology, Dialysis and
نوع کنگره / همایش بین المللی
کشور محل برگزاری کنگره/ همایش Iran (Islamic Republic)
شهر محل برگزاری کنگره/ همایش تهران
سال انتشار/ ارائه شمسی 1400
سال انتشار/ارائه میلادی 2021
تاریخ شمسی شروع و خاتمه کنگره/همایش 1400/07/28 الی 1400/08/02
آدرس لینک مقاله/ همایش در شبکه اینترنت http://www.ijkd.org/index.php/ijkd/article/view/6899/1331
آدرس علمی (Affiliation) نویسنده متقاضی Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

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نویسنده نفر چندم مقاله
مریم زارع نهندیاول
فریما آفرنددوم
حسن رضازادهسوم
علی بناگذارمحمدیچهارم

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عنوان متن
کلمات کلیدیSerum وAcetaminophen و CKD وPatients
خلاصه مقالهIntroduction. Due to the relatively high prevalence of acetaminophen poisoning worldwide especially in developed counteries, the serum level of acetaminophen is measured by default in all poisonings of unknown origin. Patients poisoned or suspected of unknown agent poisoning sometimes also develop renal insufficiency, On the other hand the authors have observed positive serum acetaminophen level (measured in the laboratory by spectrophotometry) in some patients with kidney disease without poisoning with acetaminophen (despite the patient not taking acetaminophen). As a result, acetaminophen poisoning can misdiagnose in these patients, leading to unnecessary treatments and additional costs. Therefore, in this study, the relationship between blood urea, creatinine levels and serum levels of acetaminophen was investigated in patients with end-stage renal disease in Tabriz Sina hospital. Methods. Thirty patients with ESRD (end-stage renal disease) who undergone hemodialysis, were included in the study. After obtaining informed consent, an additional blood sample of 5 cc was taken from the patients before dialysis. Supplementary and confirmatory O-Cresol diagnostic test was used to investigate that patient not taking acetaminophen. Spectrophotometric method was performed to determine the plasma concentration of acetaminophen. Results. In this study, the serum level of acetaminophen with a mean of 65.73 ± 9.49 micrograms/mL were high in these patients. Mean creatinine levels were 8.83 ± 2.74 mg/dl and mean urea levels were 130.67 ± 26.78 mg/dl. Conclusion. The results showed that despite not taking acetaminophen, the serum level of acetaminophen was high in these patients It seems that in ESRD, various toxins may interfere with spectrophotometry method and gives pseudo high levels of acetaminophen in the blood.

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