| خلاصه مقاله | Introduction. Due to the relatively high prevalence of acetaminophen
poisoning worldwide especially in developed counteries, the serum level
of acetaminophen is measured by default in all poisonings of unknown
origin. Patients poisoned or suspected of unknown agent poisoning
sometimes also develop renal insufficiency, On the other hand the authors
have observed positive serum acetaminophen level (measured in the
laboratory by spectrophotometry) in some patients with kidney disease
without poisoning with acetaminophen (despite the patient not taking
acetaminophen). As a result, acetaminophen poisoning can misdiagnose
in these patients, leading to unnecessary treatments and additional costs.
Therefore, in this study, the relationship between blood urea, creatinine
levels and serum levels of acetaminophen was investigated in patients
with end-stage renal disease in Tabriz Sina hospital.
Methods. Thirty patients with ESRD (end-stage renal disease) who
undergone hemodialysis, were included in the study. After obtaining
informed consent, an additional blood sample of 5 cc was taken
from the patients before dialysis. Supplementary and confirmatory
O-Cresol diagnostic test was used to investigate that patient not taking
acetaminophen. Spectrophotometric method was performed to determine
the plasma concentration of acetaminophen.
Results. In this study, the serum level of acetaminophen with a mean of
65.73 ± 9.49 micrograms/mL were high in these patients. Mean creatinine
levels were 8.83 ± 2.74 mg/dl and mean urea levels were 130.67 ± 26.78
mg/dl.
Conclusion. The results showed that despite not taking acetaminophen,
the serum level of acetaminophen was high in these patients It seems
that in ESRD, various toxins may interfere with spectrophotometry
method and gives pseudo high levels of acetaminophen in the blood. |