چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| ABSTRACT Objective: The purpose of the present study was firstly to identify the effectiveness of EudragitVR polymers (EudragitVR RL, RS, L100-55, L100, S100 and E100) in inhibition of celecoxib precipitation from buffer solutions (pH ¼ 6.8). Furthermore, the influence of EudragitVR polymers on non-sink dissolution behavior of celecoxib from solid dispersions was investigated. Methods: Solid dispersions were prepared by the rotary evaporation method. In vitro dissolution studies, FT-IR and differential scanning calorimetry were employed to characterize the formulations. Results: The results revealed that EudragitVR E100, L100 and S100 inhibited precipitation of celecoxib efficiently. It is understood that crystallization during the dissolution of solid dispersions could happen through crystallization from solid matrix following contact with the dissolution medium or from the supersaturated solution produced following dissolution. The supersaturated drug concentrations attained from the dissolution of EudragitVR -celecoxib solid dispersions were almost similar, suggesting that crystallization from solid matrix did not occur readily. However, only solid dispersions containing efficient crystallization inhibitor polymers were able to maintain the supersaturated solution up to the end of the dissolution run. Conclusion: Results revealed that the principal mechanism of attaining supersaturated solution of celecoxib from solid dispersions was related to crystallization inhibition from solution not from solid matrix. |
| نویسنده | نفر چندم مقاله |
|---|---|
| مریم مقصودی | اول |
| هادی پوراصغری اذر | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| The effect of some acrylic polymers on dissolution-1.pdf | 1400/10/08 | 1941858 | دانلود |
| The effect of some acrylic polymers on dissolution.pdf | 1400/10/08 | 1941858 | دانلود |
