چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Background: Changes in the expression of cytokines as the result of the single nucleotide polymorphisms (SNPs), can affect the incidence of multiple sclerosis (MS). Objective: To investigate the relationship between the frequencies of interleukin-10 (IL-10)-1082 A/G (rs1800896) and CCR5-delta32 genotypes and susceptibility to MS in the Iranian Azari population. Methods: IL-10-1082 A/G SNP and the CCR5-delta32 were genotyped in 152 patients suffering from MS and 242 healthy non-relatives by allele specific-PCR and simple PCR methods, respectively. Results: The frequencies of AA (37.6%) and AG (55.9%) genotypes of IL-10-1082 were significantly high in the control (P=0.021) and MS patients (P=0.015), respectively, with no statistical difference between these groups. There was no significant difference in the CCR5 gene based on the possession of wild/wild and wild/del32 genotypes between MS patients and the control group. The del32/ del32 genotype was not seen in any of the investigated groups. Tobacco (cigarettes and hookahs) consumption was higher among the MS patients (P=0.004), and this has the potential to raise the risk of MS in both the individuals and their family. However, it had no significant relation with the frequency of different genotypes of the IL-10-1082 and the CCR5. Conclusion: Our finding conclude on possible role of AA genotype of IL-10 -1082 as a protective factor in MS. |
| نویسنده | نفر چندم مقاله |
|---|---|
| محمد اصغرزاده | اول |
| داود ثناجو | دوم |
| بهروز مهدوی پور صباحی | سوم |
| حسین صمدی کفیل | چهارم |
| مهدی فرهودی | پنجم |
| داریوش سوادی اسکوئی | ششم |
| فاطمه خاکی خطیبی | هفتم |
| منوچهر فدائی | نهم |
| علی وقاری | هشتم |
| وحید اصغرزاده | دهم |
| پوریا قلیزاده | یازدهم |
| جلیل راشدی | دوازدهم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| IJI_Volume 18_Issue 3_Page 241-248.pdf | 1400/10/04 | 526054 | دانلود |
