| Orally disintegrating tablets (ODTs) rapidly disintegrate or dissolve in the oral cavity without using water. Demand for ODTs has
increased, and the field has overgrown in the pharmaceutical industry and academia. It is reported that ODTs have several
advantages over other conventional tablets. Since some of them are absorbed from the mouth, pharynx, and esophagus as the
saliva passes down into the stomach, in such cases, the bioavailability of the drug improves meaningfully. Furthermore, the
immediate release property of ODTs makes them a popular oral dosage form in patients with swallowing challenges, children,
and for cases with a need for rapid onset of action. The current review article explains the features of active ingredients and
excipients used in the formulation of ODTs, discusses multiple ODT formulation and preparation techniques with their merits
and demerits, and also, offers remedies for problems associated with ODTs. Moreover, quality control steps and required
considerations are presented |