چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Telomeres, the nucleoprotein structures at the ends of eukaryotic chromosomes, have multiple roles in tumorigenesis. The shelterin complex consists of six telomere-specific proteins that are involved in the protection of the telomeres. The shelterin complex protects the telomeres from degradation, prevents the activation of unwanted repair systems, and regulates the activity of telomerase. However, alteration in the structure and function of the shelterin complex proteins may lead to tumorigenesis and cancer progression. The shelterin complex biology revealed that the manipulation of the shelterin proteins could be a new strategy in cancer therapy. In this review, we focused on shelterin components' roles in the diagnosis, prevention, and treatment of cancers. |
| نویسنده | نفر چندم مقاله |
|---|---|
| محمد یوسف معمار | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| manuscripptShel-main.pdf | 1400/09/26 | 1048511 | دانلود |
