چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | لیلا واحدی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | بیماری های گوارش و کبد |
| کد مقاله | 77548 |
| عنوان فارسی مقاله | Comparison of CD4+ and CD8+ T- lymphocyte in Helicobacter pylori-negative functional dyspepsia |
| عنوان لاتین مقاله | Comparison of CD4+ and CD8+ T- lymphocyte in Helicobacter pylori-negative functional dyspepsia |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | کنفرانس بین المللی ژنتیک و ژنومیکس انسانی |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | Yazd |
| سال انتشار/ ارائه شمسی | 1400 |
| سال انتشار/ارائه میلادی | 2021 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1400/09/10 الی 1400/09/11 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | www.yazdgenetics.ir |
| آدرس علمی (Affiliation) نویسنده متقاضی | Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| کوروش مسندی شیرازی | اول |
| مریم غفاری لاله | دوم |
| امین خامنه | سوم |
| لیلا واحدی | چهارم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Background: Functional dyspepsia (FD), with a global prevalence of 10-20%1, is usually characterized by persistent or recurrent abdominal discomfort or pain with no obvious cause2. The current study was designed to evaluate and compare CD4+ and CD8+ in Helicobacter pylori-negative functional dyspepsia with the control groups. Methods: Sixty one patients (35 patients with stomach pain and 26 with abdominal bloating), and 30 controls were reviewed based on the quantity of CD4+ and CD8+ T-cells isolated from gastric mucosa biopsy samples. The comparison between variables was analyzed with a chi-square or Fisher’s exact test and logistic regression analyses. Results: A significant difference was observed between two-group patients and control group based on CD4+ and CD8+ presence, respectively (P=0.003 and P=0.008). Furthermore, there was a significant difference between stomach pain-patients and control group with regard to CD4 count (P=0.01) and between abdominal bloating-patients and control group with regard to CD8 count (P=0.002). There was a decrease in both CD4+ and CD8+ T-cells in gastric mucosa in patients with FD with a significant reduction in the stomach pain-patients and abdominal bloating-patients in the number of CD4+ and CD8+ T-cells, respectively. Conclusion: The symptoms of FD have a positive correlation with the presence of CD4+ and CD8+ T cells in the gastric mucosa due to various factors. These T cells might play an important role in inflammation, which might help to find a more specific therapy for FD. |
| کلمات کلیدی | Functional dyspepsia, T-lymphocytes, Helicobacter pylori, CD4, CD8. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Poster FD.jpg | 1400/09/15 | 3275460 | دانلود |
| FD.pdf | 1400/09/15 | 630270 | دانلود |
