چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | وحدت پورطهماسبی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | بیماری های عفونی و گرمسیری |
| کد مقاله | 77539 |
| عنوان فارسی مقاله | Integrated Analysis of Gene Expression Profiles of T-lymphocytes in human T cell leukemia virus type 1 (HTLV-1) associated disease: A bioinformatics analysis |
| عنوان لاتین مقاله | Integrated Analysis of Gene Expression Profiles of T-lymphocytes in human T cell leukemia virus type 1 (HTLV-1) associated disease: A bioinformatics analysis |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | کنفرانس بین المللی ژنتیک و ژنومیک انسانی |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | یزد |
| سال انتشار/ ارائه شمسی | 1400 |
| سال انتشار/ارائه میلادی | |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1400/09/10 الی 1400/09/11 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://yazdgenetics.ir/upload/Single/Files/Poster_33720.pdf?t=637743260860019131&t=637743260860019131 |
| آدرس علمی (Affiliation) نویسنده متقاضی | Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| امین عبادی | اول |
| امید قلیزاده | سوم |
| وحدت پورطهماسبی | چهارم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Background: Human T-lymphotropic virus type 1 (HTLV-1) is the cause of adult T-cell leukemia-lymphomas (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The goal of present study was to investigating the gene expression analysis of gene expression pattern for ATL HAM/TSP. Materials and methods: Microarray gene expression profiling of T lymphocytes from HTLV-1 associated disease and healthy control were obtained from Gene Expression. Bioinformatics tools (GEO accession: GSE19080) were performed to identify differentially expressed genes (DEGs). Among the generated DEGs, we constructed protein-protein interaction (PPI) of HAM/TSM and ATL in comparison to asymptomatic carriers (ACs). Subsequently, gene ontology and PPI analysis were performed. Topological properties of each PPI were measured using Network-Analyzer, a network analysis plug-in of Cytoscape, to identify the most important functional hub genes within the networks. Results: We found that the majority of DEGs in ATL and HAM/TSP were importantly implicated in immune response categories. The nodes and edges number of normal-AC, AC-ATL and ATLHAM/TSP PPIs were 168 and 145, 116 and 97, and 275 and 327, respectively. Based on the topological analysis of protein-protein interaction networks, APP (Amyloid Beta Precursor Protein) was detected as the critical player of HTLV-1 disease progression. The expression of APP had a significant negative correlation in ATL (down-regulated) and HAM/TSP (up-regulated) samples. PTK2, PIK3R1, COPS5, CALM1 and HLA-B associated with disease progression. Conclusion: Dysregulation of immune response associated transcripts play a critical role in HTLV-1 disease progression. Immune response associated genes may be biomarker for prognosis in cancer development and therapeutic targets. |
| کلمات کلیدی | HTLV-1, ATL, HTLV-1-associated myelopathy/tropical spastic paraparesis, Gene expression |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Certificate.jpg | 1400/09/14 | 3346597 | دانلود |
| Abstract_33720.pdf | 1400/09/14 | 268807 | دانلود |
