چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| TNFa participates in a variety of physiological processes, but at supra-physiological concentrations it has been implicated in the pathology of inflammatory and autoimmune diseases. Therefore, much attention has been devoted to the development of strategies that overcome the effects of aberrant TNFa concentration. Promising strategies include drugs that destabilize the active (trimeric) form of TNFa and antagonists of TNFa receptor type I. Underpinning these strategies is the successful application of phage-display technology to identify anti-TNFa peptides and antibodies. Here, we review the development of inhibitors of the TNFa–TNF receptor system, with particular focus on the phagedisplay-assisted identification of molecules that interfere with this system by acting as inhibitors of TNFa or by sequestering TNFa away from its receptor. |
| نویسنده | نفر چندم مقاله |
|---|---|
| علی اکبر علیزاده | اول |
| شادی یعقوبی | چهارم |
| سیاوش دستمالچی | پنجم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| A mechanistic perspective clinical applications and phage display assisted discovery of TNFa inhibitors.pdf | 1400/11/12 | 2839216 | دانلود |
