چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Abstract: Triple-negativebreastcancer(TNBC)isanaggressivesubtypeofbreastcancerthatexhibits a high proliferation rate and early metastasis leading to a poor prognosis. HMGA2 is a DNA binding transcriptional regulator implicated in tumorigenesis. Here, we demonstrate that the HMGA2 promoter is demethylated in TNBC tumors, leading to increased expression of HMGA2 at both mRNA and protein levels. Importantly, high HMGA2 levels in TNBC tumors are correlated with poor prognosis. To detail the role of HMGA2 in TNBC development and progression, we studied its effectoncorecancerphenotypes. StableknockdownofHMGA2inTNBCcellsrevealedthatHMGA2 may support cell proliferation, cell migration and invasion. In addition, HMGA2 knockdown decreased cancer stem cell (CSC) features. Importantly, we found that silencing HMGA2 inhibited NF-kB signaling and lead to decreased expression of the downstream molecules IL-6 and IL-8 and reducedSTAT3pathwayactivation. OurresultsdemonstratethatHMGA2supportscancerhallmarks in TNBC and may represent a promising target for TNBC treatment |
| نویسنده | نفر چندم مقاله |
|---|---|
| بهزاد منصوری | اول |
| بهزاد برادران | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 580-HMGA2 Supports Cancer Hallmarks in Triple-Negative.pdf | 1400/09/06 | 5928419 | دانلود |
