چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | فریبا میرزائی باویل |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات کاربردی دارویی |
| کد مقاله | 77461 |
| عنوان فارسی مقاله | بررسی تاثیر ورزش ارادی بر روند فیبروز کلیوی از طریق مسیرmiR192/ TGF-β /SIP1 در رتهای نر دیابتی |
| عنوان لاتین مقاله | The effect of voluntary exercise on renal fibrosis through miR192 / TGF-β / SIP1 pathway in male diabetic rats |
| نوع ارائه | پوسترو سخنرانی |
| عنوان کنگره / همایش | چهارمین کنگره بین المللی و 25 مین کنگره ملی فیزیولوژی و فارماکولوژی |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1400 |
| سال انتشار/ارائه میلادی | 2021 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1400/07/28 الی 1400/07/30 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://cong25.phypha.ir/ |
| آدرس علمی (Affiliation) نویسنده متقاضی | Drug applied research center, Tabriz university of medical sciences |
| نویسنده | نفر چندم مقاله |
|---|---|
| فریبا میرزائی باویل | اول |
| فریبا قیاسی | دوم |
| محمد بابازاده سیس | سوم |
| فرزاد بهاری | چهارم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Diabetes, Exercise, miR 192, TGF-β, SIP 1 |
| خلاصه مقاله | Background and aim: Diabetes is one of the most common chronic diseases in the world, the complications of which, including kidney disease, put a lot of pressure on the health system. Therefore, in this study, in order to provide a solution to improve the condition, we examined the effect of exercise through one of the pathways involved in the occurrence of this complication. Method: In this study, 48 male Wistar rats were randomly divided into 4 groups (n=12). Control group: received only streptozotocin solvent. Diabetic group: fed a high-fat diet for 5 weeks, then a dose of streptozotocin (35 mg / kg/IP) induced type 2 diabetes and maintained for 10 weeks. Voluntary exercise group: The animals did voluntary exercise for 10 weeks. Diabetes and voluntary exercise group: The animals became diabetic and performed voluntary exercise for 10 weeks. At the end of the intervention, anesthetized animals and blood and kidney tissue samples were collected to measure the expression of micRNA192 and TGF-β) Transforming Growth Factor-Beta) and SIP1(Smad-interacting protein-1(proteins by Western blotting method. Results: Compared to the control group, diabetes significantly increased all factors except SIP1(p<0.05), while exercise alone had no effect on them. Exercise with diabetes significantly reduced all factors except SIP1 compared with the diabetes group. (p<0.05). Conclusion: Diabetes can promote diabetic nephropathy by increasing extracellular matrix by increasing TGF-β and subsequent increase in miRNA192 and inhibition of SIP1. But exercise with diabetes with its opposite effect can probably prevent diabetic nephropathy. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| phy pha25-2.pdf | 1400/09/06 | 2969077 | دانلود |
| Dr Babazade.JPG | 1400/09/06 | 137278 | دانلود |
