| We aimed to evaluate the effect of Cuminum Cyminum (CC) supplementation on lipid
profile and selected anthropometric parameters. PubMed, Scopus, Web of Science, and
Embase databases were systematically searched until May 2021. The random-effect
model was used to study the effect sizes. The sources of heterogeneity were assessed
using subgroup analysis and meta-regression. Publication bias was studied by funnel
plots. The GRADE approach was used to assess the overall quality of the evidence.The
data from our eight included studies have indicated that CC supplementation can lower
body mass index (BMI) (WMD = 0.88 kg/m2; 95%CI: 1.58, 0.18; p = .023) and
total cholesterol (TC) (WMD = 3.96 mg/dl; 95%CI: 6.51, 1.04; p=.008). Also, after
adjusting for publication bias, CC was shown to be effective in improving waist circumference (WC), high-density lipoprotein (HDL-C), and triglycerides (TG) levels. Although,
the current evidence has not shown that CC supplementation can affect low-density
lipoprotein (LDL-C), our subgroup analysis has indicated that CC supplementation with
supplementation length of more than 8 weeks is associated with beneficial effects on
LDL-C.While CC might be a suitable choice in managing BMI and TC, further highquality studies are needed to confirm its efficacy in the clinical setting. |