چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| لیلا حسینی | اول |
| مهدی فرهودی | دوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Mitochondria are vital for metabolic homeostasis in all multicellular eukaryotes. In the nervous system, mitochondria generated adenosine triphosphate is required to establish proper electrochemical gradients and reliable synaptic transmission. Notably, several mitochondrial defects have been identified in central nervous system (CNS) disorders. Membrane leakage and electrolyte imbalances, pro-apoptotic pathway activation, and mitophagy are among the mechanisms involved in the pathogenesis of neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and Huntington’s disease, as well ischemic stroke. In current review, we summarize mitochondrial pathways that contribute to disease progression. Mitochondrial transplantation therapy is an innovative strategy for the mitochondrial dysfunction treatment. The approach has been reported to be useful in the treatment of myocardial ischemic reperfusion insults in human clinical trials and has been demonstrated to be useful in animal studies as a method for treating mitochondrial dysfunction in numerous tissues, including the heart, liver, lungs, and brain. On the other hand, there is no methodology for using preserved mitochondria. Research into the pharmaceutical formulation of mitochondria to promote mitotherapy as the next step in treating many patients is instantly needed. We overview previous studies on the therapeutic effects of mitochondrial transplantation and also, discussed strategies and tissue sources for mitochondria isolation as a novel approach for CNS disorders therapy. |
| کلمات کلیدی |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Leila Hosseini_Certificate.pdf | 1400/09/01 | 261020 | دانلود |
| NVND-2021-leila hosseini.pdf | 1400/09/01 | 76784 | دانلود |
| NVND-2021-Program_2.pdf | 1400/09/01 | 4195931 | دانلود |
