Magnetic sulfonated polysaccharides as efficient catalysts for synthesis of isoxazole-5-one derivatives possessing a substituted pyrrole ring, as anti-cancer agents
Magnetic sulfonated polysaccharides as efficient catalysts for synthesis of isoxazole-5-one derivatives possessing a substituted pyrrole ring, asanti-cancer agents
نویسندگان: سجاد عزیزی خواجه , جعفر سلیمانی
کلمات کلیدی: Magnetic sulfonated polysaccharides, catalysts, synthesis of isoxazole-5-one derivatives
نشریه: 30728 , 2021 , 11 , 2021
| نویسنده ثبت کننده مقاله |
جعفر سلیمانی |
| مرحله جاری مقاله |
تایید نهایی |
| دانشکده/مرکز مربوطه |
مرکز تحقیقات آنالیز دارویی |
| کد مقاله |
77418 |
| عنوان فارسی مقاله |
Magnetic sulfonated polysaccharides as efficient catalysts for synthesis of isoxazole-5-one derivatives possessing a substituted pyrrole ring, as anti-cancer agents |
| عنوان لاتین مقاله |
Magnetic sulfonated polysaccharides as efficient catalysts for synthesis of isoxazole-5-one derivatives possessing a substituted pyrrole ring, asanti-cancer agents |
| ناشر |
5 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ |
بلی |
| عنوان نشریه (خارج از لیست فوق) |
|
| نوع مقاله |
Original Article |
| نحوه ایندکس شدن مقاله |
ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
|
| Four polysaccharides (chitosan, cellulose, starch, and pectin) were magnetized with magnetic iron oxide
(Fe3O4) and then sulfonated (except pectin) with chlorosulfonic acid. The obtained solid acids were used
as a catalyst in three-component reactions between N-substituted-2-formylpyrrole, hydroxylaminehydrochloride, and b-keto esters for the synthesis of 4-(2-pyrrolyl) methylene-isoxazole-5-ones. The
optimal catalyst system was selected and studied by IR, SEM, TEM and XRD methods. The diverse
isoxazoline derivatives (obtained via a mild and simple approach) were also fully characterized by
spectroscopic methods and screened for anti-cancer activities against HT-29 and MCF-7 colon and
breast cancer and HEK 293 normal cells. The results revealed interesting anti-cancer activities. |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| 31 (1).pdf | 1400/08/30 | 1031158 | دانلود |
