چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| سپیده زنونی واحد | اول |
| محمد رضا اردلان | دوم |
| جلال اعتمادی خیاوی | سوم |
| ترانه مجیدی | چهارم |
| سیده مینا حجازیان | پنجم |
| فرهنوش فرنود | ششم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Introduction. Post-transplant diabetes mellitus (PTDM) is a common complication of organ transplantation leading to transplant dysfunction. Cytokines and genetic alterations of inflammatory cytokines have been reported to be associated with glucose homeostasis or diabetes. The proinflammatory cytokine IL-17 is involved in glucose metabolism and the pathogenesis of diabetes by inducing a low-degree inflammation. The aim of this study was to evaluate the rs763780 polymorphism of IL-17F gene in transplant patients with and without PTDM. Methods. This study was performed on 91 patients who have received a kidney allograft for at least 3 months. Patients were divided into two subgroups: patients with PTDM (n = 32) and patients without PTDM (n = 59). The ARMS-PCR was used for the evaluation of specific polymorphism. Clinical and demographic data of patients were collected. Results. PTDM was detected in 81.3% (n = 26) of TT genotype carriers, 12.5% of TC genotype carriers, and 6.3% of CC genotype carriers. There was no statistically significant difference between the case and control groups in the frequency of T and C alleles and the distribution of the abovementioned genotypes (P ≥ 0.721). In PTDM group, graft rejection and age of patients was significantly higher (P ≤ 0.017). Conclusion. No significant correlation was observed between the incidence of diabetes and rs763780 polymorphism of IL-17F gene. |
| کلمات کلیدی | Polymorphism, IL-17 Gene, Post-transplant Diabetes Mellitus |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| IJKD_V15_Supplement_1_Final.pdf | 1400/08/25 | 2832374 | دانلود |
| IL-17 PTDM.pdf | 1400/10/06 | 153681 | دانلود |
| il17 ptdm.jpg | 1400/10/06 | 142087 | دانلود |
| IMG-20220103-WA0010.jpg | 1400/10/13 | 210427 | دانلود |
