چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| سپیده زنونی واحد | اول |
| سیده مینا حجازیان | دوم |
| محمد رضا اردلان | سوم |
| الهام احمدیان | چهارم |
| فرهنوش فرنود | پنجم |
| سیما عابدی آذر | ششم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Dicer, peripheral blood mononuclear cell, nephrotic syndrome |
| خلاصه مقاله | Introduction. MicroRNAs are small non-coding RNAs that repress gene expression at both transcriptional and translational levels. Maturation of miRNAs is mediated by Dicer and Drosha, RNA polymerases, in cytoplasm and nucleus. Some in vivo studies reported that Dicer may participate in the pathogenesis of proteinuria and glomerulosclerosis Methods. In the present study, the expression levels of Dicer was evaluated in PBMC samples of drug-resistant NS patients (n = 60) using quantitative Real-Time PCR (q-PCR). A group of healthy individuals (n = 30) were also included. Results. Dicer expression level was upregulated in NS group under treatment when compared to healthy controls. Conclusion. Dysregulation of Dicer is associated with NS. These findings confirms that disruption in normal miRNA processing Dicer may play a role in NS and response to therapy |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| IJKD_V15_Supplement_1_Final.pdf | 1400/08/25 | 2832374 | دانلود |
| dicer.jpg | 1400/10/06 | 125435 | دانلود |
| Dicer.pdf | 1400/10/06 | 126734 | دانلود |
| IMG-20220103-WA0010.jpg | 1400/10/13 | 210427 | دانلود |
