چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| نگین فرزامی کیا | اول |
| محمد رضا اردلان | دوم |
| سپیده زنونی واحد | سوم |
| سیده مینا حجازیان | چهارم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Telomeric KIR Gene, CMV Infection, Acute Rejection, Kidney Transplantation |
| خلاصه مقاله | Introduction. Cytomegalovirus (CMV) infection is a common complication after organ transplantation. Natural killer cells remove the CMV-infected cells by killer-cell immunoglobulin-like receptors (KIRs). The presence of activating KIR genes may reduce the rate of CMV infection. We studied 101 kidney transplanted recipients to elucidate the correlation between number of inhibitory and activating genes and incidence of CMV infection in kidney transplanted recipients. Methods. Kidney transplanted recipients including 51 CMV+ and 50 CMV- were identified and genotyped for the presence or absence of 4 activating (KIR2DS1, KIR2DS5, KIR3DS1, KIR2DS4) and 2 inhibitory (KIR3DL1, KIR2DL5a) genes using polymerase chain reaction sequencespecific primers (PCR-SSP) assay. Results. Our results showed that CMV infection was occurred in 51 kidney transplanted patients (50.49%). In addition, there was a significant correlation between the presence of the KIR2DS2 activating gene, in the CMV- group (73.6%) compared to the CMV+ group (P = 0.033) (Figure). Conclusion. Our results confirmed that the prevalence of KIR activating genes could inhibit the incidence of CMV infection after kidney transplantation. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| IJKD_V15_Supplement_1_Final.pdf | 1400/08/25 | 2832374 | دانلود |
| Certificate 18th-Congress - Names-63Dr Farzamkia.pdf | 1400/09/22 | 1334487 | دانلود |
