چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| سیده مینا حجازیان | اول |
| محمد رضا اردلان | دوم |
| سپیده زنونی واحد | سوم |
| یلدا رهبرسعادت | چهارم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Introduction. Nephrotic syndrome (NS) is a common inflammatory kidney disorder within proteinuria. Glucocorticoids are the first line treatment for NS patients. Moreover, microRNAs are small non-coding molecules that involve in regulation of gene expression at transcription or translation levels. According to involvement of microRNAs in regulation of treatment with glucocorticoids, the aim of study was to investigate of miR-16-5p expression level in patients with NS. Methods. Blood samples of 60 patients with primary NS and 24 healthy volunteers were collected for evaluation of miR-16-5p expression level. Moreover, in-silico analysis was performed for more investigating of important signaling pathways and hubgens of the miR-16-5p. Results. Obtained results showed that miR-16-5p expression levels in NS (P = 0.022) and FSGS (P = 0.013) patients were significantly decreased when compared to controls. In-silico analysis showed 10 dominant signaling pathway within 10 hubgen for microRNAs. Conclusion. This study showed that although miR-16-5p expression levels significantly altered in PBMCs of NS patients in compared to healthy controls, but more studies should be performed for determining of diagnosis values. In-silico analysis approved that miR-16-16-5p may affect NS patients via targeting cell cycle and p53 gene. |
| کلمات کلیدی | microRNA-16, Nephrotic Syndrome, Glomerulonephritis |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| IJKD_V15_Supplement_1_Final.pdf | 1400/08/25 | 2832374 | دانلود |
| Time Table 14 - Link.pdf | 1400/08/25 | 949060 | دانلود |
