چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| رضا رهبرقاضی | اول |
| سجاد تقی زاده | دوم |
| مهدی احمدی | سوم |
| مهرداد محمدرحیمی | چهارم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Background and Aim: Melatonin is proved to be effective for reducing the complications of metabolic disorders. Here, we examined the effectof melatonin on pathological changes in lung tissue of high-fat diet-fed rats. Methods: Eighteen adult male rats were randomly divided into three groups (each in 6). The animals in high-fat-diet group were given regimeconsisted of 22% fat, 20% protein and 48% carbohydrate for 12 weeks. To assess therapeutic effect of melatonin, we used 3 mg/kbW melatonintwice weeks intraperitoneally in the last four weeks. Finally, animals were euthanized and pathological changes in lung tissue were analyzed. Results: Data showed increased high fat diets increased pathological changes (interstitial pnenomumia, and emphysema) in pulmonary tissue.The administration of melatonin reduced pathological changes and reached near-to-control levels. Conclusion: In general, melatonin diminished high-fat diet induced pathological changes in pulmonary tissue of rats. These data show thatmelatonin could be suitable therapeutics in the amelioration of high-fat diet-induced pathologies in lung tissue. |
| کلمات کلیدی | HFD; lung tissue; Melatonin; pathological changes |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Ism_certificate (2).pdf | 1400/08/24 | 2969077 | دانلود |
| Article list.pdf | 1400/08/24 | 1267384 | دانلود |
