چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Thiosemicarbazides have the capability of killing the cancerous tumor cells and inhibit the growth of bacteria and fungus. Here, we designed and synthesized a calix[4]arene-based thiosemicarbazone Schif-base ligand, and the derivative complexes with Co (II), Ni (II), Cu (II), and Zn (II) transition metals. All compounds were characterized by FT-IR spectroscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, 1 H-NMR, and ESI-Mass spectroscopy to confrm the successful synthesis. We further evaluated the biocompatibility and biological inhibitory properties of our newly synthesized complexes in human cell lines. The antibacterial activity of the ligand and derivative complexes with cobalt, nickel, copper, and zinc showed that they are all more active against gram-negative bacteria than against gram-positive ones. Hemolysis assay results demonstrated that Zn and Ni complexes have high blood compatibility in high (1600 mg L−1) and low (25 mg L−1) concentrations, respectively. MTT assay showed the substantial anticancer activity of Cu complex against the MG-63 cell line |
| نویسنده | نفر چندم مقاله |
|---|---|
| حسین صمدی کفیل | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Calix4arenebased thiosemicarbazide Schiff-base ligand and its transition metal complexes synthesis and biological assessment.pdf | 1400/08/18 | 2296110 | دانلود |
