چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Background: Stachys schtschegleevii (SSC) is a herbal medicine used to treat infections. To date, this is the first study aimed to investigate the effects of SSC tea on disease activity score (DAS), serum inflammatory biomarkers and matrix metallo-proteinases (MMP-1 and MMP-3) among women with rheumatoid arthritis (RA). Methods: This pilot, triple-blind, randomized controlled clinical trial was conducted among forty-four women (age: 30–65 years) diagnosed with moderately active RA. Subjects were randomly assigned (1:1 ratio) into either SSC group (2.4 g/day SSC + 2.4 g/day black tea, n=22) or placebo (2.4 g/day black tea, n=22) for 8 weeks. Serum high-sensitivity C-reactive protein (hs-CRP), interleukin-1 beta (IL-1β), and MMPs were measured using ELISA. According to the American College of Rheumatology guideline considering hs-CRP, DAS28 was assessed. Results: Both study groups had respondent rates above 94.9%. The SSC intervention caused significant reductions in the number and the percent changes of the tender joints (SSC: −74.39%vs.placebo: −57.15%, mean differences= −0.77; P<0.05) and DAS28 [SSC: −32.44% vs.placebo: −22.32%, mean differences= −0.41, P<0.05). Unlike the intervention within SSC group that showed significant reductions in the mean serum levels of hs-CRP, IL-1β, and MMP-3, SSC caused significant MMP-3 reductions (SSC: −20.59%vs.placebo: 1.29%, P<0.05). Conclusion: The SSC intervention showed an appropriate clinical efficacy for female RA patients, accompanying remarkable reductions in the number of tender and swollen joints, DAS28, and serum levels of MMP-3. This can provide additional insights to the interventional studies controlling RA-related pathological and inflammatory outcomes. Trial registrationProspectively registered at the Iranian Registry of Clinical Trials (IRCT), linked to the WHO Registry Network (https:// en. irct. ir/ trial/ 11602, IRCT registration number: IRCT2015032011335N5, Registration date:2015-05-12). |
| نویسنده | نفر چندم مقاله |
|---|---|
| الهام میرطاهری | اول |
| علیرضا خبازی اسکویی | دوم |
| حسین ناظمیه | سوم |
| علی اصغر ابراهیمی چهارم | چهارم |
| مهرزاد حاج علیلوی بناب | پنجم |
| زهرا شکیبای نوین | ششم |
| سعید پیروزپناه | هفتم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Stachysschtschegleeviiteamatrixmetalloproteinaseanddisease....pdf | 1401/02/29 | 1128813 | دانلود |
