| خلاصه مقاله | To date, hemodialysis (HD) is the most common therapy for
chronic kidney disease (CKD) patients. However, it causes different
complications such as sleep disorders. Sleep regulation is mediated
by vitamin D hence, its deficiency impacts the quality and duration
of sleep. This study aimed to evaluate the correlation of sleep quality
and vitamin D levels in 80 hemodialysis patients. Before beginning of
dialysis, serum 25 (OH) D levels were assessed among patients and
the sleep patterns and sleep quality of patients were accurately calculated by Pittsburgh sleep quality index (PSQI) standard questionnaire. Our results showed that 22 hemodialysis patients (27.5%) had
severe sleep disorders. In addition, it was found that serum levels of
vitamin D had significant correlation with sleep quality (r = -0.341, p
= 0.002) in general, even after adjusting confounding factors such as
Calcium, phosphate, and PTH level. In poor sleepers (PSQI ≤ 5), a negative correlation was observed between the levels of vitamin D and
PSQI score (r = -0.397, p = 0.004). PSQI scores in the normal range of
PTH (r = -0.377, p = 0.006) and in >600 pg/ml of PTH (r = -0.675, p =
0.011) had correlation with vitamin D levels. The level of vitamin D
was the single independent predictor of sleep efficiency (β coefficient
= -0.386, p = 0.001). The present project reported the positive effect
of vitamin D on sleep disorders in HD patients. In future studies, normal levels of calcium and phosphate should be considered along with
normal vitamin D levels among the included patients. |