| Background: Despite growing concern about the increasing global burden of obesity, there
are still many uncertainties in understanding the pathogenesis of this disease. This study
aimed to investigate the serum levels of 2-arachidonoylglycerol (2-AG), neuropeptide Y
(NPY), and omentin, concerning dietary patterns in obese women. Materials and Meth-
ods: This case-control study was carried on an equal number of obese (case group) and
normal-weight women (n=45 each). Dietary intake was determined based on the food fre-
quency questionnaire. Serum levels of 2-AG, NPY, and omentin were determined using
ELISA. Results: The obese group showed significantly higher 2-AG and NPY levels than
the controls(P<0.001). There were significant positive correlations between the serum lev-
el of 2-AG and calorie intake (r=0.219, P=0.038), carbohydrates (r=0.238, P=0.024), fat
(r=0.227, P=0.032), saturated fatty acids (r=0.272, P=0.009), and monounsaturated fatty ac-
ids (r=0.265, P=0.012). Conclusion: Our study revealed that dietary patterns, in particular,
the type of fatty acids used may influence levels of 2-AG, NPY, and omentin, which all are
involved in pathways resulting in obesity. |