A new correlative model to simulate the solubility of drugs in mono-solvent systems at various temperatures
A new correlative model to simulate the solubility of drugs in mono-solvent systems at various temperatures
نویسندگان: ابوالقاسم جویبان , الهه رحیم پور , زهرا کریم زاده
کلمات کلیدی: SolubilityPredictionMono-solventsCorrelationPharmaceuticalsvan’t Hoff equation
نشریه: 18106 , 2021 , 343 , 2021
| نویسنده ثبت کننده مقاله |
ابوالقاسم جویبان |
| مرحله جاری مقاله |
تایید نهایی |
| دانشکده/مرکز مربوطه |
مرکز تحقیقات آنالیز دارویی |
| کد مقاله |
77221 |
| عنوان فارسی مقاله |
A new correlative model to simulate the solubility of drugs in mono-solvent systems at various temperatures |
| عنوان لاتین مقاله |
A new correlative model to simulate the solubility of drugs in mono-solvent systems at various temperatures |
| ناشر |
3 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ |
بلی |
| عنوان نشریه (خارج از لیست فوق) |
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| نوع مقاله |
Original Article |
| نحوه ایندکس شدن مقاله |
ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
|
| A simple model is proposed for correlating the solubility of a given drug in different mono-solvents at various temperatures. The model is based on the well-known van’t Hoff equation and employs a combination of Abraham, Hansen and Catalan parameters as variables representing the drug-solvent interactions in the solutions. The proposed model correlates the solubility of each drug in different mono-solvents at various temperatures. The accuracy of the model for correlating the data was investigated by calculating the mean percentage deviation of the back-calculated data and the corresponding experimental values. Thirty solubility data sets were collected randomly from the recently published articles. The obtained results are promising and the novel model could be recommended for further investigations. |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| J Mol Liq 343 (2021) 117587.pdf | 1400/08/09 | 492479 | دانلود |