چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Podocytes, highly specified kidney epithelial cells, live under several pathological stimuli and stresses during which they adapt themselves to keep homeostasis. Nevertheless, under extreme stress, a complex scenario of podocyte damage and its consequences occur. Podocyte damage causes foot process effacement and their detachment from the glomerular basement membrane, leading to proteinuria. Podocyte‐derived extracellular vesicles (pEVs), mainly microparticles and exosomes are considered as signaling mediators of intercellular communication. Recently, it has been shown that throughout the injury‐related migration procedure, podocytes are capable of releasing the injury‐related migrasomes. Evidence indicates that at the early stages of glomerular disorders, increased levels of pEVs are observed in urine. At the early stage of nephropathy, pEVs especially migrasomes seem to be more sensitive and reliable indicators of podocyte stress and/or damage than proteinuria. This review highlights the current knowledge of pEVs and their values for the diagnosis of different kidney diseases. |
| نویسنده | نفر چندم مقاله |
|---|---|
| محمد رضا اردلان | اول |
| سید مهدی حسینی یان خطیبی | دوم |
| یلدا رهبرسعادت | سوم |
| زیبا نریمان صالح فام | پنجم |
| سیما عابدی آذر | ششم |
| سپیده زنونی واحد | هشتم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Migrasomes and exosomes different types of messaging.pdf | 1400/10/08 | 1385417 | دانلود |
