چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Introduction: Indirect hyperbilirubinemia is one of the most common causes of hospitalization in the neonatal period and its potential association with brain damage is well established. This study was conducted to determine neurodevelopmental outcome of children who had severe indirect hyperbilirubinemia in neonatal period and had received intensive phototherapy with or without double volume exchange transfusion for its management. Methods: This descriptive analytical study was performed in healthy infants with the history of severe indirect hyperbilirubinemia who needed intensive phototherapy with or without exchange transfusion. We followed up the enrolled infants at their 2-3 years age. Neurodevelopmental assessment was performed by a trained nurse using Ages and Stages Questionnaire. Results: The mean level of total serum bilirubin (TSB) of the studied children was 26.4±4.1 mg/dL at their neonatal period. The estimated rate of severe hyperbilirubinemia 48.7/100 000 live born infants for the patients with the TSB of 25-30 mg/dL and 11.4 /100 000 for hyperbilirubinemia with TSB levels higher than 30 mg/dL. The most common cause of jaundice in patients with exchange transfusion was ABO incompatibility. At their follow up examination, the classic form of bilirubin induced encephalopathy (Kernicterus) was diagnosed in 3 neonates. Two of them had sensory neural hearing loss, too. Eleven children had low score based on ASQ in at least one area. The score was less than 2 SD in 3 patients.Conclusion: Severe hyperbilirubinemia and kernicterus is still occurring in term and late pre- term infants. Early detection and management of severe hyperbilirubinemia may improve the neurodevelopmental outcome in high risk infants. |
| نویسنده | نفر چندم مقاله |
|---|---|
| منیژه مصطفی قره باغی | اول |
| سیف اله حیدرآبادی | دوم |
| معصومه قاسمپور | سوم |
| مهسا علیزاده | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| jrcm-9-1.pdf | 1400/08/04 | 234668 | دانلود |
