The role of PI3K signaling pathway and its associated genes in papillary thyroid cancer
The role of PI3K signaling pathway and its associated genes in papillary thyroid cancer
نویسندگان: الهام امجد سقین سرا , سولماز اثناعشری , بابک سکوتی
کلمات کلیدی: Papillary thyroid cancer, Meta-analysis, GEO datasets, Signaling pathway, Biomarker
نشریه: 21797 , 11 , 33 , 2021
| نویسنده ثبت کننده مقاله |
بابک سکوتی |
| مرحله جاری مقاله |
تایید نهایی |
| دانشکده/مرکز مربوطه |
مرکز تحقیقات بیوتکنولوژی(زیست فناوری) |
| کد مقاله |
76949 |
| عنوان فارسی مقاله |
The role of PI3K signaling pathway and its associated genes in papillary thyroid cancer |
| عنوان لاتین مقاله |
The role of PI3K signaling pathway and its associated genes in papillary thyroid cancer |
| ناشر |
3 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ |
خیر |
| عنوان نشریه (خارج از لیست فوق) |
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| نوع مقاله |
متاآنالیز |
| نحوه ایندکس شدن مقاله |
ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
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| Background
One of the well-differentiated types of thyroid cancer is papillary thyroid cancer (PTC), often developed by genetic mutations and radiation.
Methods
In this study, the public NCBI-GEO database was systematically searched. The eligible datasets were the targets for biomarker discovery associated with PI3K signaling pathway.
Results
Only two datasets were suitable and passed the inclusion criteria. The meta-analysis outcomes revealed eleven upregulation and thirteen downregulation genes differentially expressed between PTC and healthy tissues. Moreover, the outcomes for survival and disease-free rates for each gene were illustrated.
Conclusions
The present research suggests a panel signature of 24 gene biomarkers in diagnosing the PTC. |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| s43046-021-00068-2.pdf | 1400/07/10 | 2573428 | دانلود |