چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| miRNAs are involved in different biological processes, including proliferation, differentiation, and apoptosis. Interestingly, 38% of the X chromosome-linked miRNAs are testis-specific and have crucial roles in regulating the renewal and cell cycle of spermatogonial stem cells. Previous studies demonstrated that abnormal expression of spermatogenesis-related miRNAs could lead to nonobstructive azoospermia (NOA). Moreover, differential miRNAs expression in seminal plasma of NOA patients has been reported compared to normozoospermic men. However, the role of miRNAs in NOA pathogenesis and the underlying mechanisms have not been comprehensively studied. Therefore, the aim of this review is to mechanistically describe the role of miRNAs in the pathogenesis of NOA and discuss the possibility of using the miRNAs as therapeutic targets. |
| نویسنده | نفر چندم مقاله |
|---|---|
| یگانه راستگاررضایی | اول |
| رضا زارع زاده | دوم |
| صبا نیکان فر | سوم |
| فرناز عقبائی | چهارم |
| زهرا بهرامی | ششم |
| نصرت اله ضرغامی | هفتم |
| یداله احمدی عصربدر | هشتم |
| امیر فتاحی | نهم |
| محمد نوری | دهم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| miRNA and azoospermia.pdf | 1400/07/03 | 1003375 | دانلود |
