چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Abstract: Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS) that is characterized by inflammation which typically results in significant impairment in most patients. Immune checkpoints act as co-stimulatory and co-inhibitory molecules and play a fundamental role in keeping the equilibrium of the immune system. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) and Programmed death-ligand 1 (PD-L1), as inhibitory immune checkpoints, participate in terminating the development of numerous autoimmune diseases, including MS. We assessed the CTLA-4 and PD-L1 gene expression in the different cell types of peripheral blood mononuclear cells of MS patients using single-cell RNA-seq data. Additionally, this study outlines howCTLA-4andPD-L1expressionwasalteredinthePBMCsamplesofrelapsing-remittingmultiple sclerosis(RRMS)patientscomparedtothehealthygroup. Finally,itinvestigatestheimpactofvarious MS-related treatments in the CTLA-4 and PD-L1 expression to restrain autoreactive T cells and stop the development of MS autoimmunity. |
| نویسنده | نفر چندم مقاله |
|---|---|
| افشین درخشانی | اول |
| زهرا اسدزاده | اول |
| مهدی عبدلی شادباد | پنجم |
| بهزاد برادران | هفتم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 556-Regulation of CTLA-4 and PD-L1Experession in Relapsing-Remitting Multiple Sclerosis Patients after Treatment with Fingolimod IFN beta-1 alpha Glatiramer Acetate,and Dimethyl Fumarate Drugs.pdf | 1400/07/04 | 8991496 | دانلود |
