چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Aim: This research aims to develop potential therapeutic nanostructures (NSs) encapsulating metformin (MET) and erlotinib (ER) for combinational therapy in breast cancer. Methods: The ER and MET, both were loaded on mesoporous silica magnetic nanoparticles conjugated with polyethylene glycol and methotrexate to achieve targeted NSs. The developed NSs were characterized using SEM, DLS, and FTIR. Afterward, MTT, Trypan blue, and DNA extraction assays were operated for biological evaluations in the 2D and 3D MCF-7 cells. Results: Physicochemical approaches indicated the mean diameter of 69.4 nm ± 9.5 (PDI=0.64), and neutral charge (2 mv) for the developed NSs. MET and ER-loaded NSs exhibited 62.56 % ± 4.41 and 67.73 % ± 3.03 drug release amount in pH=5.4, respectively. MTT assay revealed that ER- and MET-loaded NSs had less metabolic activity (≈ 20%) in comparison with non-targeted NSs. Conclusion: Overall, our combined ER, and MET-loaded targeted NSs result in a synergistic inhibitory impact on MCF-7 cells. |
| نویسنده | نفر چندم مقاله |
|---|---|
| ژاله برار | هفتم |
| خسرو ادیب کیا | هشتم |
| نسترن هاشم زاده | اول |
| ایوب آقانژاد | دوم |
| الهه دلیرعبدالهی نیا | سوم |
| میترا دولت خواه | چهارم |
| محمد برزگر جلالی | پنجم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Reserach 2-hashemzadeh.pdf | 1400/07/13 | 3214062 | دانلود |
