| Background: We aimed to investigate the determinants of Health-related quality of life (HRQOL) in Iranian patients
with celiac disease (CD) using the structural equation modeling (SEM).
Methods: In the present cross-sectional study, a total of 170 adult patients with CD were recruited. The information
regarding adherence to diet, symptom severity, and HRQOL were collected using the celiac disease adherence test
(CDAT), gastrointestinal symptom rating scale (GSRS), and SF-36 questionnaire respectively. Association between various studied variables and HRQOL was assessed using SEM. The standardized regression weights were used to assess
total, direct and indirect efects. The model ft indices were used to assess the “goodness of ft” between the hypothesized models.
Results: The mean age of participants was 37.57±9.59 years. The results of SEM indicated that the overall ft of our
model was acceptable. Adherence to the diet, GSRS score, occupation, and education level was signifcantly related
to PCS of SF-36; and adherence to the diet, GSRS score, and education level were signifcantly correlated with MCS of
SF-36. The analysis of indirect associations indicated that only adherence to diet indirectly via GSRS score was signifcantly associated with PCS and MCS of SF-36.
Conclusion: In adult patients with celiac disease, HRQOL was associated with age, education, adherence to GFD,
and GSRS score. Additionally, occupation and disease duration were associated with HRQOL only in women and men
respectively. |